AN ADAPTIVE TWO-ARM CLINICAL TRIAL USING EARLY ENDPOINTS TO INFORM DECISION MAKING: DESIGN FOR A STUDY OF SUB-ACROMIAL SPACERS FOR REPAIR OF ROTATOR CUFF TENDON TEARS

Abstract Background There is widespread concern across the clinical and research communities that clinical trials, powered for patient-reported outcomes, testing new surgical procedures are often expensive and time-consuming, particularly when the new intervention is shown to be no better than the standard.Conventional (non-adaptive) randomised con

In view of problems of difficult detection and high risk in manual vision inspection of balancing tail rope failures of hoist, an on-line monitoring and early warning system of balancing tail rope of hoist based on machine vision was designed.The system uses CCD camera to real-timely Toys collect on-site images of tail ropes of hoist, extracts char

The evolution of display technologies makes high dynamic range/wide color gamut (HDR/WCG) media of great interest QUICK-BLAST in various applications including cinema, TV, blue-ray titles, and others.However, the HDR/WCG media format for consumer electronics requires the sampling rate conversion of chroma signals, resulting in a quality problem on

Exosomes, as pivotal entities within the tumor microenvironment, orchestrate intercellular communication through the transfer of diverse molecules, among which non-coding RNAs (ncRNAs) such as miRNAs, lncRNAs, and circRNAs play a crucial role.These ncRNAs, endowed with regulatory functions, are selectively incorporated into exosomes.Emerging eviden

Full assurance of safety during mass events is a complex process, subject to provisions of generally applicable law.These provisions regulate in detail all basic obligations and requirements provided for this particular kind Short Sleeve Shirts of events.However, in the course of time some of the regulations provided for in the Polish legal system